Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma

@article{Ligon2007Olig2RegulatedLP,
  title={Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma},
  author={Keith L Ligon and Emmanuelle Huillard and Shwetal Mehta and Santosh Kesari and Hongye Liu and John A. Alberta and Robert M. Bachoo and Michael F. Kane and David N Louis and Ronald A. Depinho and David J. Anderson and Charles Dean Stiles and David H Rowitch},
  journal={Neuron},
  year={2007},
  volume={53},
  pages={503-517}
}
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically… CONTINUE READING
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Glioma stem cells

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