Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa.

@article{Genter1995OlfactoryTO,
  title={Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa.},
  author={Mary Beth Genter and Nora J Deamer and Bonita L Blake and D S Wesley and Pierrette Levi},
  journal={Toxicologic pathology},
  year={1995},
  volume={23 4},
  pages={477-86}
}
Methimazole is a compound administered to humans for the treatment of hyperthyroidism and is used experimentally as a model substrate for the flavin-containing monooxygenase (FMO) system. Previous results from this laboratory demonstrated that methimazole is an olfactory system toxicant, causing nearly complete destruction of the olfactory epithelium in the male Long-Evans rat following a single ip dose of 300 mg/kg. The present studies were undertaken to determine the dose-response… CONTINUE READING

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