Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease

@article{Doty1993OlfactoryTD,
  title={Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease},
  author={Richard L. Doty and Lawrence I Golbe and Donald A. Mckeown and Matthew B. Stern and C M Lehrach and Donah Crawford},
  journal={Neurology},
  year={1993},
  volume={43},
  pages={962 - 962}
}
Olfactory dysfunction occurs in most patients with idiopathic Parkinson's disease (PD). In this study, we sought to determine whether such dysfunction is also present in progressive supranuclear palsy (PSP), a condition which shares a number of motor symptoms with PD and is commonly misdiagnosed as PD. We administered the University of Pennsylvania Smell Identification Test, a standardized test of odor identification ability, to 21 PSP patients; 17 also received a forced-choice odor detection… 
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Analysis of testing for odor threshold, olfactory discrimination and identification in idiopathic Parkinson's disease (IPD) and nonidiopathy Parkinson's syndrome (PS) added to previous findings and suggested that Olfactory probes improve the diagnostic armamentarium in IPD.
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The University of Pennsylvania Smell Identification Test (UPSIT) was applied to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination, 140 patients with nondemented Parkinson's disease (PD) and 126 controls and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon.
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TLDR
Significantly different scores on the University of Pennsylvania Smell Identification Test (UPSIT) were present between patients with benign PD and malignant PD, and women outperformed men in most subtypes examined.
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TLDR
Marked olfactory impairment was a feature of the patients with PD, while mild OE impairment was observed in those with MSA or PSP, which may also be useful in differentiating PD from related disorders.
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Olfactory testing as an aid in the diagnosis of Parkinson's disease: development of optimal discrimination criteria.
  • R. Doty, S. M. Bromley, M. Stern
  • Psychology, Medicine
    Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration
  • 1995
Since olfactory dysfunction is among the first signs of idiopathic Parkinson's disease (PD), olfactory testing may aid in the early of 'preclinical' diagnosis of this disorder. Indeed, the proportion
The odor stick identification test for Japanese differentiates Parkinson's disease from multiple system atrophy and progressive supra nuclear palsy
TLDR
The OSIT-J is a potentially useful clinical test not only for detection of olfactory deficit in PD but also for differentiating PD from MSA-P and PSP.
Olfactory dysfunction in familial parkinsonism
TLDR
Olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype, and the appearance of olfactoryfunction soon after disease onset raises the possibility of it being part of the neurodegenerative disease process.
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