Olfactory system involvement in natural scrapie disease.

  title={Olfactory system involvement in natural scrapie disease.},
  author={Cristiano Corona and Chiara Porcario and Francesca Martucci and Barbara Iulini and Barbara Manea and Marina Gallo and Claudia Palmitessa and Cristiana Maurella and Maria Mazza and Marzia Pezzolato and Pier Luigi Acutis and Cristina Casalone},
  journal={Journal of virology},
  volume={83 8},
The olfactory system (OS) is involved in many infectious and neurodegenerative diseases, both human and animal, and it has recently been investigated in regard to transmissible spongiform encephalopathies. Previous assessments of nasal mucosa infection by prions following intracerebral challenge suggested a potential centrifugal spread along the olfactory nerve fibers of the pathological prion protein (PrP(Sc)). Whether the nasal cavity may be a route for centripetal prion infection to the… CONTINUE READING