Olfactory neurons are protected from apoptosis in adult transgenic mice over-expressing the bcl-2 gene.

@article{Jourdan1998OlfactoryNA,
  title={Olfactory neurons are protected from apoptosis in adult transgenic mice over-expressing the bcl-2 gene.},
  author={François Jourdan and Emmanuel Moyse and Fabienne de Bilbao and Michel L Dubois-Dauphin},
  journal={Neuroreport},
  year={1998},
  volume={9 5},
  pages={921-6}
}
The olfactory system provides a useful in vivo model for studying neuronal apoptosis. The synaptic target deafferentation (olfactory bulb ablation) of the sensory epithelium induces a massive and synchronous wave of retrograde apoptosis in the large population of olfactory sensory neurons. The proto-oncogene bcl-2 is involved in the regulation of cell death… CONTINUE READING