Olfactory-like receptor cDNAs are present in human lingual cDNA libraries.

@article{Durzyski2005OlfactorylikeRC,
  title={Olfactory-like receptor cDNAs are present in human lingual cDNA libraries.},
  author={Lukasz Durzyński and J. C. Gaudin and Magdalena Myga and Jarosław W Szydłowski and A. Gozdzicka-jozefiak and Thomas Haertl{\'e}},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 1},
  pages={
          264-72
        }
}
Olfactory and pheromone receptors (ORs) constitute a large family of G-protein-coupled receptors involved in the detection and transduction of odorant signals. Using degenerated primers complementary to the highly conserved transmembrane domains II, III, VI, and VII within this protein family, Gaudin et al. have recently described the expression of several OR genes in foetal human tongue. Among the nine genes identified in human foetal tongue (HTPCR06, HGMP07I, JCG6, TPCR85, JCGI1, JCG2, JCG3… 
Mouse orthologs of human olfactory-like receptors expressed in the tongue.
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TLDR
The results support the idea that ORs are broadly expressed in a variety of tissues and provide the basis for further functional studies.
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TLDR
Observations suggest that OMP expression is a reliable indicator of OR-mediated chemoreception, may be used to identify ectopically expressed ORs, and could participate in second messenger signaling cascades that mediate fertility.
4.30 – Structure, Expression, and Function of Olfactory Receptors
TLDR
The detailed pharmacology of ORs has revealed agonist and antagonist specificity and has led to functional determination of the odorant-binding site, which provides the molecular basis for odorant sensitivity and specificity.
Olfactory receptors in non-chemosensory tissues
TLDR
The results of a research series that identifies ectopic expressions and functions of ORs in non-chemosensory tissues to provide insight into future research directions are presented.
Profiling of Olfactory Receptor Gene Expression in Whole Human Olfactory Mucosa
TLDR
A TaqMan Low Density Array (Applied Biosystems), containing probes for 356 predicted human olfactory receptor loci is designed to investigate their expression in whole human Olfactory mucosa tissues and provide an opportunity to select the frequently expressed and potentially functional olfFactory receptors in view of a systematic deorphanization.
Mammalian Taste Cells Express Functional Olfactory Receptors.
TLDR
Olfactory receptors are functionally expressed in taste papillae of green fluorescent protein-expressing transgenic mice and, using immunocytochemistry and real-time quantitative polymerase chain reaction experiments, the presence of olfactory signal transduction molecules and ofactory receptors in cultured human fungiform taste papilla cells is found.
Computerized screening of G-protein coupled receptors to identify and characterize olfactory receptors
TLDR
Developing computerized programs to differentiate ORs from GPCRs indicates that this novel method may be considered as a tool for identification and characterization of receptors which might aid in therapeutic approaches to human chemical-mediated sensitization.
Ectopic Expression of Mammalian Olfactory Receptors
TLDR
This chapter highlights the expression and function of ORs outside the olfactory epithelium of the nose, which are attributed to have potential as diagnostical and therapeutical tools as ORs are differentially expressed in pathological tissues.
Widespread ectopic expression of olfactory receptor genes
TLDR
The OR superfamily as a whole, show widespread, locus-dependent and heterogeneous expression, in agreement with a neutral or near neutral evolutionary model for transcription control, which cannot reject the possibility that small OR subsets might play functional roles in different tissues.
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TLDR
The obtained results imply that lingual olfactory-like receptors could be involved in taste perception, although functional studies are needed before definitive conclusions are made.
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TLDR
The male germ line from each mammalian species tested is characterized by a specific repertoire of olfactory receptors, which display a pattern of expression suggestive of their potential implication in the control of sperm maturation, migration, or fertilization.
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The deduced amino acid sequence of the rat OL1 receptor, together with its expression at high levels in a small subset of cells in the olfactory neuroepithelium indicate that OL1 is related to the recently discovered olf factory multigene family.
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TLDR
It is found that humans have accumulated mutations that disrupt OR coding regions roughly 4-fold faster than any other species sampled, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes.
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TLDR
A full-length cDNA clone encoding a tongue cell-type specific receptor is described, which is similar to known G protein-coupled, seven-transmembrane receptors such as an olfactory receptor but is significantly different in part.
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TLDR
The cloning of 16 human OR genes, all from chromosome 17 (17p13.3), suggest that the cluster identified may be one of several copies of an ancestral OR gene repertoire whose existence may predate the divergence of mammals.
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TLDR
In addition to the cDNA fragments available previously, this work reports the molecular cloning of two olfactory receptor cDNAs from a human testis library and sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family.
Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels
TLDR
Olfactory function of over one-third of the intact mouse olfactory receptors is confirmed, and the finding that different olfFactory receptors have different expression levels is intriguing given the one-neuron, one-gene expression regime of olf factory receptors.
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TLDR
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TLDR
The results of this analysis suggest the following genome expansion history: first, the generation of a "tetrapod-specific" Class II OR cluster on chromosome 11 by local duplication, then a single-step duplication of this cluster to chromosome 1, and finally an avalanche of duplication events out of chromosome 1 to most other chromosomes.
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