Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia

  title={Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia},
  author={Claudia I. Rupp and Walter Wolfgang Fleischhacker and Georg Kemmler and Christian Kremser and Robert M. Bilder and Sergei Mechtcheriakov and Philip R. Szeszko and Thomas Walch and Arne W. Scholtz and Martina Klimbacher and Claudia Maier and Gudrun Albrecht and Theresia Lechner-Schoner and Stefan Felber and Hartmann Hinterhuber},
  journal={Schizophrenia Research},
Olfactory Functioning in Schizophrenia: Relationship to Clinical, Neuropsychological, and Volumetric MRI Measures
Poorer odor identification scores were associated with longer duration of illness, increased negative and disorganized symptoms, and the deficit syndrome, as well as impairments in verbal and nonverbal memory.
Orbitofrontal volume deficit in schizophrenia and thought disorder.
A subregion-specific OFC grey matter volume deficit in patients with schizophrenia was demonstrated, which was independent of OFC sulcogyral pattern and associated with a longer duration of illness and greater formal thought disorder.
Brain regions associated with olfactory dysfunction in first episode psychosis patients.
  • S. Etyemez, Z. Narita, A. Sawa
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2022
The left SFG may be a promising brain region in the context of olfactory dysfunction and negative symptoms in FEP, through both hypothesis-driven (centred on the SFG) and data-driven approaches.
Executive function and memory in relation to olfactory deficits in alcohol-dependent patients.
Findings add to the available research on frontal lobe dysfunction in alcoholism, suggesting that alcohol-related olfactory discrimination deficits may be associated with impairment in the functional integrity of the prefrontal lobe.
Olfactory Dysfunction in Schizophrenia: A Review of Neuroanatomy and Psychophysiological Measurements
This article summarizes recent research on neuroimaging changes associated with olfactory impairments in schizophrenia patients and on related functional changes in psychophysiological measurements (e.g., odor identification, odor discrimination, odor detection threshold, and odor memory).
Contributions of Olfactory and Neuropsychological Assessment to the Diagnosis of First-Episode Schizophrenia
Findings indicate that manual dexterity, letter-guided word fluency, and odor discrimination may provide incremental information that strengthens a diagnosis of SZ+, and that odor discrimination tasks may have utility over odor identification measures as a neurodevelopmental risk marker.
Size matters - The olfactory bulb as a marker for depression.
Olfactory Functioning in First-Episode Psychosis
Findings indicate that olfactory deficits extend beyond measures of odor identification in FEP with greater deficits observed in schizophrenia-related subgroups of psychosis.
Automated Immunohistochemical Analysis of the Orbitofrontal Cortex in Patients with Schizophrenia, Bipolar Disorder and Major Depressive Disorder
The entire OFC in patients with MDD, BP and SCZ was analyzed using a novel approach with layer-specific immunohistochemical markers and an automated counting protocol, suggesting that inconsistencies in the literature may arise from sampling only small areas of the cortex in a limited number of subjects.


Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia.
Patients with schizophrenia have reduced cortical volumes in brain regions that receive afferents directly from the olfactory bulb, which is related to structural brain abnormalities in these regions.
Olfactory dysfunction in schizophrenia and temporal lobe epilepsy.
Data suggest a greater reliance of olfactory processing on right hemisphere structures in schizophrenia and are consistent with recent neuroimaging studies that have implicated aberrant processing of Olfactory information in right hemispheric brain regions in schizophrenia.
Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms.
The results suggest that gray matter deficits may be a fairly common structural abnormality of schizophrenia, whereas reductions in prefrontal white matter may be associated with schizophrenic negative symptoms.
Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia.
Sch schizophrenia is associated with reduced gray matter volume in prefrontal cortex, which affects men and women in the dorsolateral sector and the effects are moderated by sex for dorsomedial and orbital regions and are related to symptom severity and cognitive function.
Temporolimbic volume reductions in schizophrenia.
In men, reduction was manifested in all regions, whereas women showed decreased hippocampal volumes but increased amygdala volumes, which correlate more strongly with cognitive performance than with symptom severity in patients with first-episode schizophrenia.