Olfactory exposure to males, including men, causes stress and related analgesia in rodents

@article{Sorge2014OlfactoryET,
  title={Olfactory exposure to males, including men, causes stress and related analgesia in rodents},
  author={Robert E Sorge and Loren J Martin and Kelsey A. Isbester and Susana G. Sotocinal and Sarah F Rosen and Alexander H. Tuttle and Jeffrey S. Wieskopf and Erinn L Acland and Anastassia Dokova and Basil Kadoura and Philip Leger and Josiane C. S. Mapplebeck and Martina McPhail and Ada Delaney and Gustaf Wigerblad and Alan P Schumann and Tammie L Quinn and Johannes Frasnelli and Camilla I. Svensson and Wendy Faith Sternberg and Jeffrey S. Mogil},
  journal={Nature Methods},
  year={2014},
  volume={11},
  pages={629-632}
}
We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing. 
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References

SHOWING 1-10 OF 21 REFERENCES
Exposure to a cat produces opioid analgesia in rats.
TLDR
In both experiments, rats tested in the presence of the cat showed a significant reduction in sensitivity/reactivity to a skin-irritating formalin injection, and naltrexone reversed this analgesia.
Male scent-induced analgesia in the deer mouse, Peromyscus maniculatus: Involvement of benzodiazepine systems
TLDR
The results indicate that exposure of male deer mice to the olfactory cues associated with a potentially threatening individual (dominant/aggressive isolated male) elicits an analgesic response that involves alterations in the activity of benzodiazepine systems.
Opioid and Nonopioid Swim Stress-Induced Analgesia: A Parametric Analysis in Mice
TLDR
In selectively bred mice, analgesia and hypothermia from forced swimming are positively correlated, but can be dissociated both genetically and neurochemically, and swimming in body temperature water produces analgesia without concommitant Hypothermia.
Stress-induced analgesia
TLDR
The study of stress-induced analgesia has enhanced the understanding of the fundamental physiology ofPain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.
Female perception of male body odor.
TLDR
This chapter reviews research on olfactory communication among humans, focusing on the effects of male bodily odors on female physiology and behavior and evidence regarding the influence of the major histocompatibility complex and fluctuating asymmetry on male Olfactory cues.
Smelling of Odorous Sex Hormone-like Compounds Causes Sex-Differentiated Hypothalamic Activations in Humans
TLDR
It is shown that women smelling an androgen-like compound activate the hypothalamus, with the center of gravity in the preoptic and ventromedial nuclei, which suggests a potential physiological substrate for a sex-differentiated behavioral response in humans.
Smelling a Single Component of Male Sweat Alters Levels of Cortisol in Women
TLDR
It was found that merely smelling androstadienone maintained significantly higher levels of the hormone cortisol in women, suggesting that, like rodents, humans can influence the hormonal balance of conspecifics through chemosignals.
Innate versus learned odour processing in the mouse olfactory bulb
TLDR
It is shown that, in dorsal-zone-depleted mice, the dorsal domain of the olfactory bulb was devoid of glomerular structures, although second-order neurons were present in the vacant areas, which indicates that aversive information is received in the ofactory bulb by separate sets ofglomeruli, those dedicated for innate and those for learned responses.
Coding of facial expressions of pain in the laboratory mouse
TLDR
The mouse grimace scale (MGS) is developed, a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain.
Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state.
TLDR
Evidence is found that grooming mice are relatively hypoalgesic, and robustly so in the von Frey test such that even the largest usable fibers are met with indifference, which is problematic for algesiometric testing in the mouse.
...
1
2
3
...