Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.

@article{Arnold2010OlfactoryEA,
  title={Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.},
  author={Steven E Arnold and Edward K. B. Lee and Paul J. Moberg and Lauren D Stutzbach and Hala Altaf Kazi and Li-ying Han and Virginia M. Y. Lee and John Q. Trojanowski},
  journal={Annals of neurology},
  year={2010},
  volume={67 4},
  pages={462-9}
}
OBJECTIVE Olfactory dysfunction is common in Alzheimer disease (AD) and other neurodegenerative diseases. Paired helical filament (PHF)-tau, alpha-synuclein, and amyloid-beta lesions occur early and severely in cerebral regions of the olfactory system, and they have also been observed in olfactory epithelium (OE). However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established. METHODS We investigated the… CONTINUE READING
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