Olfactory dysfunction occurs in transgenic mice overexpressing human τ protein

@article{Macknin2004OlfactoryDO,
  title={Olfactory dysfunction occurs in transgenic mice overexpressing human τ protein},
  author={Jonathan B. Macknin and Makoto Higuchi and Virginia M. -Y. Lee and John Q. Trojanowski and Richard L Doty},
  journal={Brain Research},
  year={2004},
  volume={1000},
  pages={174-178}
}
Disorders of olfaction are among the first clinical signs of neurodegenerative diseases such as Alzheimer's disease (AD) and idiopathic Parkinson's disease (PD). In this study, we employed an odor habituation paradigm to evaluate the olfactory function of T alpha 1-3RT transgenic mice that overexpress tau, a key pathogenic protein in AD, and compared such function to that of wild-type controls who do not overexpress this protein. The T alpha 1-3RT mice, but not the controls, exhibited responses… CONTINUE READING
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