Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases.

@article{Goldstein2009OlfactoryDI,
  title={Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases.},
  author={David S Goldstein and Latoya Sewell},
  journal={Parkinsonism & related disorders},
  year={2009},
  volume={15 7},
  pages={
          516-20
        }
}
BACKGROUND Pure autonomic failure (PAF) and Parkinson disease (PD) both are Lewy body diseases, and both entail substantia nigra dopaminergic, locus ceruleus noradrenergic, and cardiac sympathetic denervation. Multiple system atrophy (MSA) is a non-Lewy body disease in which alpha-synuclein accumulates in glial cells, with central catecholamine deficiency but preserved cardiac sympathetic innervation in most patients. PD is associated with more severe and consistent olfactory dysfunction than… CONTINUE READING
Highly Cited
This paper has 38 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Pure Autonomic Failure.

Current neurology and neuroscience reports • 2016