Olfactory dysfunction in parkinsonism

  title={Olfactory dysfunction in parkinsonism},
  author={Richard L. Doty and Daniel A. Deems and Stanley Stellar},
  pages={1237 - 1237}
To explore the nature of the olfactory dysfunction associated with Parkinson's disease (PD), 81 PD patients who scored well on a cognitive screening test were administered the 40-odorant University of Pennsylvania Smell Identification Test; 38 were additionally given a forced-choice phenylethyl alcohol odor detection threshold test. Clinical ratings of 11 neurologic symptoms (three bilateral) were obtained at the time of testing, and odor identification was retested in 24 patients at intervals… 

Figures from this paper

The olfactory and cognitive deficits of parkinson's disease: Evidence for independence
Findings lend support to the hypothesis that the olfactory disorder of parkinsonism is independent of the cognitive, perceptual‐motor, and memory manifestations of the disease.
Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease
It is demonstrated that patients with PSP and PD differ markedly in their ability to smell and suggest that olfactory testing may be useful in their differential diagnosis.
Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test.
With the use of the B-SIT, 5 specific odors appear primarily affected in patients with Parkinson disease, and the ability of patients to detect some odors was unimpaired compared with that of controls.
Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson’s disease
It is concluded that patients withPD have selective hyposmia, and a simplified UPSIT smell identification test consisting of 3 PD-selective odors had more robust correlation with nigral and dorsal striatial dopaminergic activity compared with the full UPSIT scores in patients with PD.
Olfactory function in Parkinsonian syndromes
Analysis of testing for odor threshold, olfactory discrimination and identification in idiopathic Parkinson's disease (IPD) and nonidiopathy Parkinson's syndrome (PS) added to previous findings and suggested that Olfactory probes improve the diagnostic armamentarium in IPD.
Olfactory tests in the diagnosis of essential tremor.
Olfactory Deficits in the Freezing of Gait Phenotype of Parkinson's Disease
A 3-odorant score helped categorize freezers and non-freezers with similar sensitivity and specificity to short odorant Parkinson's disease identification batteries.
Invalid Self-Assessment of Olfactory Functioning in Parkinson's Disease Patients May Mislead the Neurologist
It is demonstrated that olfactory self-assessments show a low accuracy and are not suitable for the diagnosis of a smell disorder in PD.
Olfactory dysfunction in Parkinson’s disease: Benefits of quantitative odorant examination
The present study indicated that hyposmia inPD patients increased from HY II onwards, and a single odorant of methyl cyclopentenolone or skatol had benefits for olfactory evaluation in PD patients.
University of Pennsylvania Smell Identification Test Abnormalities in Parkinson's Disease.
Olfactory loss is a significant non motor symptom in Parkinson's disease patients and is probably not related to the disease duration, stage or severity of motor symptoms.


Olfactory threshold in Parkinson's disease.
Olfactory threshold to differing concentrations of amyl acetate was determined in 78 subjects with idiopathic Parkinson's disease and 40 age-matched controls and there was no significant correlation between olfactory thresholds and age, sex, duration of disease, or current therapy with levodopa or anticholinergic drugs.
Differences in olfactory test performance between normal aged, Alzheimer and vascular type dementia individuals
Differences in age and severity of dementia did not fully account for the findings, suggesting that differential diagnosis of Alzheimer ‐ type dementia could be facilitated and improved by the use of olfactory tasks.
Olfactory function in patients with Parkinson's disease.
Correlates of Memory in Parkinson's Disease
A recently developed standardized test of recent memory functions to 53 idiopathic parkinsonian patients undergoing Sinemet treatment correlated consistently and pervasively with impaired memory.
Olfactory impairment in Parkinson's disease
In comparison with closely matched controls, patients with Parkinson's disease had reduced scores in tests of odor detection and qualitative discrimination and seemed to be a nonmotor manifestation of the disease.
Measurements of visual evoked potentials in Parkinson's disease.
In 5 patients the latency became less prolonged on levodopa therapy, suggesting that catecholaminergic pathways have either indirect or direct effects on the generation of visual evoked potentials.
Factor analysis of Parkinson's impairment. An evaluation of the final common pathway.
The question of how pathophysiologic mechanisms may combine to yield significant performance impairment in Parkinson's disease was studied by factor analysis of the covariation among behavioral
Judgment of visual and postural vertical by parkinsonian patients
Investigating whether basal ganglia disease might produce abnormalities similar to those found after penetrating trauma of the convexity of man’s frontal lobes found that these abnormalities were significantly greater than those after injuries to the posterior third of the brain, or in normal controls.