Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.

@article{Hellier2010OlfactoryDV,
  title={Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.},
  author={Jennifer L. Hellier and Nicole L. Arevalo and Megan J Blatner and An K Dang and Amy C. Clevenger and Catherine E. Adams and Diego Restrepo},
  journal={Brain research},
  year={2010},
  volume={1358},
  pages={140-50}
}
Previous studies have shown that schizophrenics have decreased expression of α7-nicotinic acetylcholine (α7) receptors in the hippocampus and other brain regions, paranoid delusions, disorganized speech, deficits in auditory gating (i.e., inability to inhibit neuronal responses to repetitive auditory stimuli), and difficulties in odor discrimination and detection. Here we use mice with decreased α7 expression that also show a deficit in auditory gating to determine if these mice have similar… CONTINUE READING
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