Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.

Abstract

Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats. Olfactory bulbectomy performed 7 days prior to pilocarpine administration has a strong protective effect against the seizures. Neuropathological changes which normally occur in this seizure model do not develop in the brains of bulbectomized animals.

Cite this paper

@article{Milln1986OlfactoryBP, title={Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.}, author={Manuel Mill{\'a}n and Shanon Patel and Brian S. Meldrum}, journal={Brain research}, year={1986}, volume={398 1}, pages={204-6} }