Olfactory bulb ablation in the rat: behavioural changes and their reversal by antidepressant drugs.

@article{Riezen1977OlfactoryBA,
  title={Olfactory bulb ablation in the rat: behavioural changes and their reversal by antidepressant drugs.},
  author={H van Riezen and Harold Schnieden and Allison F Wren},
  journal={British journal of pharmacology},
  year={1977},
  volume={60 4},
  pages={
          521-8
        }
}
1. The effects of bilateral olfactory bulbectomy, sham-operation and inducement of peripheral anosmia were studied on locomotor activity, passive avoidance acquisition and irritability. 2. Bulbectomized rats were hyperactive, deficient at learning a step-down passive avoidance response and hyperirritable. Peripheral anosmia, induced by intranasal infusion of ZnSO4 solution resulted in no behavioural changes. 3. Chronic pretreatment with amitriptyline (3 and 10 mg/kg) and a tetracyclic… CONTINUE READING
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