Olfactory behavior and physiology are disrupted in prion protein knockout mice

@inproceedings{Pichon2009OlfactoryBA,
  title={Olfactory behavior and physiology are disrupted in prion protein knockout mice},
  author={Claire E Le Pichon and Matthew T. Valley and Magdalini Polymenidou and Alexander T Chesler and Botir T Sagdullaev and Adriano Aguzzi and Stuart Firestein},
  booktitle={Nature Neuroscience},
  year={2009}
}
The prion protein PrPC is infamous for its role in disease, but its normal physiological function remains unknown. Here we found a previously unknown behavioral phenotype of Prnp−/− mice in an odor-guided task. This phenotype was manifest in three Prnp knockout lines on different genetic backgrounds, which provides strong evidence that the phenotype is caused by a lack of PrPC rather than by other genetic factors. Prnp−/− mice also showed altered behavior in a second olfactory task, suggesting… CONTINUE READING
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