Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

  title={Oleuropein aglycone protects against pyroglutamylated-3 amyloid-\ss toxicity: biochemical, epigenetic and functional correlates},
  author={Ilaria Luccarini and Cristina Grossi and Stefania Rigacci and Elisabetta Coppi and Fiorella Casamenti},
  journal={Neurobiology of Aging},
Amyloid-ß (Aß) fragments, oligomeric Aß aggregates, and pyroglutamylated-Aß peptides, as well as epigenetic mechanisms and autophagy dysfunction all appear to contribute in various ways to Alzheimer's disease progression. We previously showed that dietary supplementation of oleuropein aglycone, a natural phenol abundant in the extra virgin olive oil, can be protective by reducing Aß42 deposits in the brain of young and middle-aged TgCRND8 mice. Here, we extended our study to aged TgCRND8 mice… CONTINUE READING


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