Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin

@article{Geusau1999OlestraIF,
  title={Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin},
  author={Alexandra Geusau and E Tschachler and Michael Meixner and S. Sandermann and Olaf P{\"a}pke and Christian Wolf and Eva Valic and Georg Stingl and Michael D. McLachlan},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={1266-1267}
}
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years. 
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