Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin

  title={Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin},
  author={Alexandra Geusau and E Tschachler and Michael Meixner and S. Sandermann and Olaf P{\"a}pke and Christian Wolf and Eva Valic and Georg Stingl and Michael D. McLachlan},
  journal={The Lancet},
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years. 
Severe 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) intoxication: Insights into the measurement of hepatic cytochrome P450 1A2 induction *
The performance of several modifications of the caffeine test for measurement of CYP1A2 activity in subjects with exceptionally high, low, or absent enzyme induction is compared. Expand
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients
Abstract. In spring 1998, two women were diagnosed with severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication. Over the following 3 years, TCDD levels were monitored under various attemptsExpand
Cutaneous elimination of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) is excreted via the faeces, breast milk and epidermal lipids after exposure to TCDD. Expand
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites
This case of poisoning with TCDD suggests that the design of methods for routine assessment ofTCDD metabolites in human beings should be a main aim of T CDD research in the metabolomic era. Expand
Nonabsorbable dietary fat enhances disposal of 2,2',4,4'-tetrabromodiphenyl ether in rats through interruption of enterohepatic circulation.
Dietary supplementation of nonabsorbable fat can enhance excretion of hydrophobic POPs by interruption of their enterohepatic circulation, and data indicate that this strategy could decrease concentrations of hydrophic POPs in the human body and thereby their impact on human health. Expand
Increasing Effect of Nori on the Fecal Excretion of Dioxin by Rats
The results suggest that the administration of nori prevented dioxin from being efficiently absorbed and reabsorbed from the gastrointestinal tract, and might be useful for protecting humans exposed to dioxIn from ill effects. Expand
Seaweed accelerates the excretion of dioxin stored in rats.
The effects of seaweed such as wakame, hiziki, and kombu on the gastrointestinal absorption and reabsorption of 17 types of polychlorinated dibenzo-p-dioxin and polychlorination dibenzofuran congeners was investigated in Wistar rats. Expand
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects.
A 2-year follow-up is presented including clinical, biochemical, hematologic, endocrine, and immunologic parameters monitored in two women, 30 and 27 years of age, who suffered from chloracne due to TCDD intoxication of unknown origin. Expand
2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model.
The most prominent effect of TCDD was an increase of thickness of the stratum corneum with parakeratosis and a reduction of viable cell layers after 7 d of treatment, compared with vehicle-treated samples. Expand
Half-lives of tetra-, penta-, hexa-, hepta-, and octachlorodibenzo-p-dioxin in rats, monkeys, and humans--a critical review.
The elimination half-lives of polychlorinated dibenzo-p-dioxins in humans from the rat data are critically compared with measured t1/2 values of PCDDs and other persistent organic pollutants in rats, monkeys and humans. Expand


A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans.
It is concluded that regular consumption of olestra may provide a therapeutic approach for reducing the body burden of persistent lipophilic contaminants. Expand
Clearance of PCDD/Fs via the gastrointestinal tract in occupationally exposed persons.
A digestive tract mass balance was performed on men with high body burdens of polychlorinated dibenzo-p-dioxins and dibenzofurans, showing that the gastrointestinal pathway plays a decisive role in the clearance of most 2,3,7,8-subsituted PCDD/F congeners. Expand
The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity.
Human risk assessment for PCDDs and PCDFs needs to consider species-, congener-, and dose-specific toxicokinetic data, as exposure to complex mixtures, including PCBs, has the potential to alter the toxicokinetics of individual compounds. Expand
Intake, Fecal Excretion, and Body Burden of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Breast-Fed and Formula-Fed Infants
Accumulation of PCDDs and PCDFs in infants is as high as expected on the basis of intake data and assuming complete absorption and negligible elimination during the 1st y of life. Expand
Chloracne and its potential clinical implications
  • K. Crow
  • Medicine
  • Clinical and experimental dermatology
  • 1981
Animal experiments demonstrate conclusively that the effects of an arbitrary amount of any chloracneigenic toxin are less severe as a single dose than if given in divided doses over a longer period. Expand