Oleoyl-estrone lowers the body weight of both ob/ob and db/db mice.

  title={Oleoyl-estrone lowers the body weight of both ob/ob and db/db mice.},
  author={M M Grasa and Ruth Vil{\`a} and Montserrat Esteve and Cristina G{\'o}mez i Jordi Cabot and J A Fern{\'a}ndez-L{\'o}pez and Xavier Remesar and Mari{\`a} Alemany},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={32 6},
Homozygous obese db/db (BKS-Lepr(db) and ob/ob (B6-Lep(ob)) mice were treated for 14 days with a continuous infusion of a fat emulsion (controls) or loaded with oleoyl-estrone at doses of 12.5 and 50 nmol/g x d using surgically inserted osmotic minipumps. Treatment with oleoyl-estrone resulted in a marked decrease in body weight in both strains, compared with the unchecked growth of controls. In db/db mice, plasma urea and insulin, as well as liver lipid decreased with treatment. In ob/ob mice… CONTINUE READING