Oleic acid is a key cytotoxic component of HAMLET-like complexes.

  title={Oleic acid is a key cytotoxic component of HAMLET-like complexes.},
  author={Sergei E Permyakov and Ekaterina L. Knyazeva and Leysan M Khasanova and Roman S. Fadeev and Andrei P Zhadan and Hazeline Roche-H{\aa}kansson and Anders P Hakansson and Vladimir S. Akatov and Eugene A Permyakov},
  journal={Biological chemistry},
  volume={393 1-2},
HAMLET is a complex of α-lactalbumin (α-LA) with oleic acid (OA) that selectively kills tumor cells and Streptococcus pneumoniae. To assess the contribution of the proteinaceous component to cytotoxicity of HAMLET, OA complexes with proteins structurally and functionally distinct from α-LA were prepared. Similar to HAMLET, the OA complexes with bovine… CONTINUE READING