Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells.

@article{Hirschi1993OleicAD,
  title={Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells.},
  author={Karen K Hirschi and B Minnich and Leah K Moore and Janis M Burt},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={C1517-26}
}
The effects of oleic acid (OA) on gap junction-mediated intercellular communication between A7r5 cells and neonatal rat cardiac myocytes were determined. In A7r5 cells the extent of dye coupling was influenced in a biphasic manner by increasing concentrations of OA. Low concentrations of OA (0.1-1 microM) reduced the incidence of dye coupling from 90% (in control cells) to approximately 50%. Further increases in OA concentration, up to 100 microM, had no further effect on extent of dye coupling… CONTINUE READING

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