Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes.

@article{Coelho2013OlefinCV,
  title={Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes.},
  author={Pedro S. Coelho and Eric M Brustad and Arvind Kannan and Frances H. Arnold},
  journal={Science},
  year={2013},
  volume={339 6117},
  pages={
          307-10
        }
}
  • Pedro S. Coelho, Eric M Brustad, +1 author Frances H. Arnold
  • Published in Science 2013
  • Chemistry, Medicine
  • Transition metal-catalyzed transfers of carbenes, nitrenes, and oxenes are powerful methods for functionalizing C=C and C-H bonds. Nature has evolved a diverse toolbox for oxene transfers, as exemplified by the myriad monooxygenation reactions catalyzed by cytochrome P450 enzymes. The isoelectronic carbene transfer to olefins, a widely used C-C bond-forming reaction in organic synthesis, has no biological counterpart. Here we report engineered variants of cytochrome P450(BM3) that catalyze… CONTINUE READING

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