Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance.

@article{Qiu2005OleatemediatedSO,
  title={Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance.},
  author={Wei Qiu and Changiz Taghibiglou and Rita Kohen Avramoglu and Stephen C Van Iderstine and Mark Naples and Homa Ashrafpour and Shailen Mhapsekar and Ryuichiro Sato and Khosrow Adeli},
  journal={Biochemistry},
  year={2005},
  volume={44 8},
  pages={3041-9}
}
Hepatic lipoprotein overproduction in a fructose-fed hamster model of insulin resistance was previously shown to be associated with a significant elevation of intracellular mass of microsomal triglyceride transfer protein (MTP) and elevated plasma levels of free fatty acids (FFA). Here, we further establish that fructose feeding and development of an insulin resistant state result in higher levels of MTP mRNA, protein mass, and lipid transfer activity. MTP protein mass was increased in fructose… CONTINUE READING

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