Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast.

  title={Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast.},
  author={Melanie Connerth and Tibor Czabany and Andrea Wagner and Guenther Zellnig and E. von Leitner and Ernst Steyrer and Guenther Daum},
  journal={The Journal of biological chemistry},
  volume={285 35},
In the yeast Saccharomyces cerevisiae, neutral lipids can be synthesized by four acyltransferases, namely Dga1p and Lro1p producing triacylglycerols (TAG) and Are1p and Are2p forming steryl esters (SE). TAG and SE are stored in an organelle called lipid particles/droplet. Growth of yeast cells on oleate-supplemented media strongly induced proliferation of lipid particles and specifically the synthesis of TAG, which serve as the major pool for the excess of fatty acids. Surprisingly, SE… CONTINUE READING


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