Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein.

@article{Villar2014OleanolicAM,
  title={Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein.},
  author={Victor Hugo Villar and Oliver V{\"o}gler and Francisca Barcel{\'o} and Manuel G{\'o}mez-Florit and Jordi Mart{\'i}nez-Serra and Ant{\`o}nia Obrador-Hevia and Javier Mart{\'i}n-broto and Valentina Ru{\'i}z-Guti{\'e}rrez and Regina Alemany},
  journal={The Journal of nutritional biochemistry},
  year={2014},
  volume={25 4},
  pages={429-38}
}
The pentacyclic triterpenes oleanolic acid (OLA) and maslinic acid (MLA) are natural compounds present in many plants and dietary products consumed in the Mediterranean diet (e.g., pomace and virgin olive oils). Several nutraceutical activities have been attributed to OLA and MLA, whose antitumoral effects have been extensively evaluated in human adenocarcinomas, but little is known regarding their effectiveness in soft tissue sarcomas (STS). We assessed efficacy and molecular mechanisms… CONTINUE READING