Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells.

@article{Wei2013OleanolicAA,
  title={Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells.},
  author={Jianteng Wei and Ming Liu and Haizhou Liu and Hui Wang and Fengxia Wang and Yuyan Zhang and Lijun Han and Xiukun Lin},
  journal={Journal of applied toxicology : JAT},
  year={2013},
  volume={33 8},
  pages={756-65}
}
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits potential anti-tumor activity against many tumor cell lines. This study aims to examine the anti-tumor activity of OA on pancreatic cancer cells and its potential molecular mechanism. The results showed that the proliferation of Panc-28 cells was inhibited by OA in a concentration-dependent manner… CONTINUE READING