Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

@article{Shanmugam2014OleanolicAA,
  title={Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.},
  author={Muthu Kumaraswamy Shanmugam and Xiaoyun Dai and Alan Prem Kumar and Benny K H Tan and Gautam Sethi and Anupam Bishayee},
  journal={Cancer letters},
  year={2014},
  volume={346 2},
  pages={
          206-16
        }
}
Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular endothelial growth factor, and poly (ADP-ribose) polymerase in a variety of tumor… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 51 CITATIONS, ESTIMATED 54% COVERAGE

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

  • European journal of medicinal chemistry
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations

  • Averaged 10 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 162 REFERENCES

3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells.

  • Phytotherapy research : PTR
  • 2012
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Synthesis

H. Sheng, H. Sun
  • biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases, Nat. Prod. Rep. 28
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

S

I. Jutooru, G. Chadalapaka, +4 authors M. Andreeff
  • Safe, Methyl 2-cyano-3,12-dioxooleana-1,9-dien- 28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a, Mol. Pharmacol. 78 (2010) 226–236. 216 M.K. Shanmugam et al. / Cancer Letters 346
  • 2014