Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction

@inproceedings{Mapanga2012OleanolicAA,
  title={Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction},
  author={Rudo F. Mapanga and Uthra Rajamani and N Dlamini and Makhosazane Zungu-Edmondson and Roisin Kelly-Laubscher and Mohammed Shafiullah and Athiq Wahab and Mohamed Yousif Hasan and M. A. Fahim and Philippe Rondeau and Emmanuel Bourdon and M Faadiel Essop},
  booktitle={PloS one},
  year={2012}
}
Diabetes constitutes a major health challenge. Since cardiovascular complications are common in diabetic patients this will further increase the overall burden of disease. Furthermore, stress-induced hyperglycemia in non-diabetic patients with acute myocardial infarction is associated with higher in-hospital mortality. Previous studies implicate oxidative stress, excessive flux through the hexosamine biosynthetic pathway (HBP) and a dysfunctional ubiquitin-proteasome system (UPS) as potential… CONTINUE READING