Oleander interference in the digoxin radioimmunoassay in a fatal ingestion.

@article{Osterloh1982OleanderII,
  title={Oleander interference in the digoxin radioimmunoassay in a fatal ingestion.},
  author={John Osterloh and Sabine Herold and Susan M. Pond},
  journal={JAMA},
  year={1982},
  volume={247 11},
  pages={1596-7}
}
An elderly woman allegedly ingested oleander leaves and died. Ventricular arrhythmias and asystole were unresponsive to cardiopulmonary resuscitation, pharmacologic agents, and cardioversion. The patient, who had no access to digoxin, had an initial serum digoxin concentration of 5.8 ng/mL. Cross-reactivities between oleander extract and pure oleandrin and digoxin in the digoxin radioimmunoassay were 100:1 and 29,000:1, respectively. We postulate that glycosides in oleander leaves produced the… CONTINUE READING