Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.

@article{Leggett2004OleamideIA,
  title={Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.},
  author={James Leggett and Sue Aspley and Simon R. G. Beckett and Aaron M D'Antona and David A. Kendall},
  journal={British journal of pharmacology},
  year={2004},
  volume={141 2},
  pages={253-62}
}
1. The ability of the endogenous fatty acid amide, cis-oleamide (ODA), to bind to and activate cannabinoid CB(1) and CB(2) receptors was investigated. 2. ODA competitively inhibited binding of the nonselective cannabinoid agonist [(3)H]CP55,940 and the selective CB(1) antagonist [(3)H]SR141716A to rat whole-brain membranes with K(i) values of 1.14 microm (0.52-2.53 microm, Hill slope=0.80, n=6) and 2.63 microm (0.62-11.20 microm, Hill slope=0.92, n=4), respectively. AEA inhibited [(3)H]CP55,940… CONTINUE READING

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