Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26

@article{Ohba2007OleamideDS,
  title={Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26},
  author={Yusuke Ohba and Yukiko Kanao and Nobuyoshi Morita and Eri Fujii and Mai Hohrai and Mayuko Takatsuji and Hideki Hirose and Daisaku Miura and Akihiro Watari and Masuo Yutsudo and Hanjun Zhao and Norikazu Yabuta and Akihiko Ito and Yasuyuki Kita and Hiroshi Nojima},
  journal={International Journal of Cancer},
  year={2007},
  volume={121}
}
We previously reported that overexpressing connexin 26 (Cx26) enhances the spontaneous metastasis of mouse BL6 melanoma cells. In contrast, daily intraperitoneal injections of an oleamide derivative named MI‐18 potently inhibits the spontaneous metastasis of BL6 cells. In the present study, we chemically synthesized a novel oleamide derivative named MI‐22 and found that it also efficiently suppressed the spontaneous metastasis of BL6 cells. Both MI‐18 and MI‐22 inhibited the gap junction… Expand
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