Older Adults, "Malignant" Left Ventricular Hypertrophy, and Associated Cardiac-Specific Biomarker Phenotypes to Identify the Differential Risk of New-Onset Reduced Versus Preserved Ejection Fraction Heart Failure: CHS (Cardiovascular Health Study).

@article{Seliger2015OlderA,
  title={Older Adults, "Malignant" Left Ventricular Hypertrophy, and Associated Cardiac-Specific Biomarker Phenotypes to Identify the Differential Risk of New-Onset Reduced Versus Preserved Ejection Fraction Heart Failure: CHS (Cardiovascular Health Study).},
  author={Stephen L. Seliger and James A. de Lemos and Ian J. Neeland and Robert H. M. Christenson and John S. Gottdiener and Mark H. Drazner and Jarett D. Berry and John David Sorkin and Christopher deFilippi},
  journal={JACC. Heart failure},
  year={2015},
  volume={3 6},
  pages={445-455}
}
OBJECTIVES This study hypothesized that biomarkers of subclinical myocardial injury (high-sensitivity cardiac troponin T [hs-cTnT]) and hemodynamic stress (N-terminal pro-B-type natriuretic peptide [NT-proBNP]) would differentiate heart failure (HF) risk among older adults with left ventricular hypertrophy (LVH). BACKGROUND The natural history of LVH, an important risk factor for HF, is heterogeneous. METHODS NT-proBNP and hs-cTnT were measured at baseline and after 2 to 3 years in older… CONTINUE READING