Old rats are unresponsive to the behavioral effects of adrenocorticotropin.


In 28 month-old male rats, the i.c.v. injection of adrenocorticotropin [ACTH-(1-24)] (4 micrograms/rat) did not induce the typical behavioral syndrome (excessive grooming, stretching, yawning, penile erections). This indicates that the behavioral effects of melanocortins are age-dependent, suggesting either an aging-linked impairment of the nervous circuitries involved or a reduction of the number (or affinity, or both) of the brain melanocortin receptors in the elderly.

Cite this paper

@article{Poggioli1994OldRA, title={Old rats are unresponsive to the behavioral effects of adrenocorticotropin.}, author={Renato Poggioli and Augusta Benelli and Rossana Arletti and Anna Valeria Vergoni and Brnedito D Menozzi and Alfio Bertolini}, journal={European journal of pharmacology}, year={1994}, volume={271 2-3}, pages={253-7} }