Old and new functions of proneural factors revealed by the genome-wide characterization of their transcriptional targets.

@article{Castro2011OldAN,
  title={Old and new functions of proneural factors revealed by the genome-wide characterization of their transcriptional targets.},
  author={Diogo S Castro and François Guillemot},
  journal={Cell cycle},
  year={2011},
  volume={10 23},
  pages={
          4026-31
        }
}
In the developing vertebrate nervous system, bHLH proneural factors such as Ascl1 are known to play important regulatory roles at different stages of the neurogenic differentiation process. In spite of the wealth of information gathered on the cellular functions of proneural factors, little was known of the molecular basis for their activities, and in particular of the identity of their target genes. The development of genomic approaches is making possible the characterization of… CONTINUE READING
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