Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F2α Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility

@article{DazViraqu2018OldYE,
  title={Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F2$\alpha$ Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility},
  author={Florencia D{\'i}az-Viraqu{\'e} and Mar{\'i}a Laura Chiribao and Andrea Trochine and Fabiola Gonz{\'a}lez-Herrera and Christian Castillo and Ana Liempi and Ulrike Kemmerling and Juan Diego Maya and Carlos Robello},
  journal={Frontiers in Immunology},
  year={2018},
  volume={9}
}
The discovery that trypanosomatids, unicellular organisms of the order Kinetoplastida, are capable of synthesizing prostaglandins raised questions about the role of these molecules during parasitic infections. Multiple studies indicate that prostaglandins could be related to the infection processes and pathogenesis in trypanosomatids. This work aimed to unveil the role of the prostaglandin F2α synthase TcOYE in the establishment of Trypanosoma cruzi infection, the causative agent of Chagas… Expand
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