Olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia

@article{Bitter2004OlanzapineVC,
  title={Olanzapine versus clozapine in treatment-resistant or treatment-intolerant schizophrenia},
  author={Istv{\'a}n Bitter and Martin R K Dossenbach and Shlomo Brook and Peter D. Feldman and for the Olanzapine HGCK Study Group},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2004},
  volume={28},
  pages={173-180}
}
Clozapine has been the gold standard for treatment of patients with refractory schizophrenia but is associated with serious safety liabilities. This has prompted the search for therapeutic alternatives for treatment-resistant schizophrenia. The objective of this study was to compare the efficacy and safety of olanzapine versus clozapine in schizophrenic patients who failed to respond adequately to antipsychotic medication or who experienced intolerable adverse effects associated with the… CONTINUE READING

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