Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis

@inproceedings{Albaugh2011OlanzapinePF,
  title={Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis},
  author={Vance L Albaugh and Jessica G. Judson and Pengxiang She and Charles H Lang and Kevin P. Maresca and John L. Joyal and Christopher J. Lynch},
  booktitle={Molecular Psychiatry},
  year={2011}
}
Olanzapine and other atypical antipsychotics cause metabolic side effects leading to obesity and diabetes; although these continue to be an important public health concern, their underlying mechanisms remain elusive. Therefore, an animal model of these side effects was developed in male Sprague–Dawley rats. Chronic administration of olanzapine elevated fasting glucose, impaired glucose and insulin tolerance, increased fat mass but, in contrast to female rats, did not increase body weight or… CONTINUE READING

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Effects of olanzapine and haloperidol on the metabolic status of healthy men.

The Journal of clinical endocrinology and metabolism • 2010
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