Olanzapine in the treatment of post-traumatic stress disorder: a pilot study.

@article{Butterfield2001OlanzapineIT,
  title={Olanzapine in the treatment of post-traumatic stress disorder: a pilot study.},
  author={Marian I. Butterfield and Mary E Becker and Kathryn M. Connor and Suzanne M Sutherland and L Erik Churchill and Jonathan R. T. Davidson},
  journal={International clinical psychopharmacology},
  year={2001},
  volume={16 4},
  pages={197-203}
}
Because the atypical antipsychotic olanzapine may be efficacious in treating post-traumatic stress disorder (PTSD) symptoms, we conducted a 10-week, double-blind, placebo-controlled evaluation in which 15 patients were randomized 2:1 to either olanzapine or placebo. The initial dosage was 5 mg/day and was titrated to a maximum of 20 mg/day. Eleven patients completed the study. Patients in both groups showed improvement in PTSD symptoms, but no between-group differences in treatment response… CONTINUE READING

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