Olanzapine in long-term treatment for bipolar disorder.
@article{Cipriani2009OlanzapineIL, title={Olanzapine in long-term treatment for bipolar disorder.}, author={Andrea Cipriani and Jennifer M. Rendell and John R. Geddes}, journal={The Cochrane database of systematic reviews}, year={2009}, volume={1}, pages={ CD004367 } }
BACKGROUND
Many patients with bipolar disorder require long-term treatment to prevent recurrence. Antipsychotic drugs are often used to treat acute manic episodes. It is important to clarify whether olanzapine could have a role in long-term prevention of manic and depressive relapses.
OBJECTIVES
To assess the effects of olanzapine, as monotherapy or adjunctive treatment, in preventing manic, depressive and mixed episodes in patients with bipolar affective disorder.
SEARCH STRATEGY
We…
35 Citations
Olanzapine in the long-term treatment of bipolar disorder: A systematic review and meta-analysis
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It is concluded that olanZapine may prevent further manic episodes only in patients who have responded to olanzapine in an acute manic or mixed episode and who have not previously had a satisfactory response to lithium or valproate.
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- Psychology, MedicineNeuropsychiatric disease and treatment
- 2010
In this review, the aspects of pharmacology, pharmacokinetics, metabolism, safety and tolerability, and clinical trials focusing on the efficacy of RLAI in bipolar disorder are considered.
Maintaining mood stability in bipolar disorder: a clinical perspective on pharmacotherapy
- PsychologyEvidence-Based Mental Health
- 2014
This review primarily included studies that were randomised, placebo-controlled, blinded, non-enriched and of sufficient duration to be regarded as maintenance therapy and their impact in determining treatment decisions was moderated accordingly.
Bipolar disorders: a review.
- Psychology, MedicineAmerican family physician
- 2012
Patients and their support systems should be educated about mood relapse, suicidal ideation, and the effectiveness of early intervention to reduce complications.
The Cost of Relapse for Patients with a Manic/Mixed Episode of Bipolar Disorder in the EMBLEM Study
- Medicine, PsychologyPharmacoEconomics
- 2012
The findings confirm the significant economic impact of relapse in BD patients after an acute manic or mixed episode, even when considering direct costs only, which were dominated by inpatient stay.
Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial.
- Medicine, PsychologyJournal of affective disorders
- 2010
Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder.
- Medicine, PsychologyThe Cochrane database of systematic reviews
- 2013
The efficacy of valproate continuation and maintenance treatment was determined in preventing or attenuating manic, depressive and mixed episodes of bipolar disorder in patients with rapid cycling disorder and in improving patients' general health and social functioning.
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