Olanzapine does not enhance cognition in non-agitated and non-psychotic patients with mild to moderate Alzheimer's dementia.

@article{Kennedy2005OlanzapineDN,
  title={Olanzapine does not enhance cognition in non-agitated and non-psychotic patients with mild to moderate Alzheimer's dementia.},
  author={John Kennedy and Walter G Deberdt and Alan P Siegal and Joseph L Micca and Elisabeth K. Degenhardt and Jonna Ahl and Adam Meyers and Christopher J Kaiser and Robert W. Baker},
  journal={International journal of geriatric psychiatry},
  year={2005},
  volume={20 11},
  pages={1020-7}
}
OBJECTIVE This was an exploratory study of olanzapine as potential treatment for improvement in cognition in patients with Alzheimer's disease without prominent psychobehavioral symptoms. METHODS Non-psychotic/non-agitated patients (n = 268) with Alzheimer's disease, who had baseline Mini-Mental State Examination (MMSE) scores of 14-26 were randomized to treatment with olanzapine (2.5 to 7.5 mg/d) or placebo for 26 weeks. The primary objectives were to determine if treatment with olanzapine… CONTINUE READING
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