Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes

  title={Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes},
  author={Staffan Haegg and Olav Spigset and H A Lakso and Rune Dahlqvist},
  journal={European Journal of Clinical Pharmacology},
Objective: Limited data suggest that CYP1A2 and CYP2D6 are involved in the metabolism of olanzapine. The purpose of this study was to further elucidate the role of these enzymes in the disposition of olanzapine in vivo. Methods: Seventeen healthy non-smoking male volunteers were included in the study. Five subjects were CYP2D6 poor metabolisers (PMs), and 12 were CYP2D6 extensive metabolisers (EMs). All subjects received a single oral dose of 7.5 mg olanzapine, and serum concentrations were… CONTINUE READING

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