Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes

@article{Haegg2001OlanzapineDI,
  title={Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes},
  author={Staffan Haegg and Olav Spigset and H A Lakso and Rune Dahlqvist},
  journal={European Journal of Clinical Pharmacology},
  year={2001},
  volume={57},
  pages={493-497}
}
Objective: Limited data suggest that CYP1A2 and CYP2D6 are involved in the metabolism of olanzapine. The purpose of this study was to further elucidate the role of these enzymes in the disposition of olanzapine in vivo. Methods: Seventeen healthy non-smoking male volunteers were included in the study. Five subjects were CYP2D6 poor metabolisers (PMs), and 12 were CYP2D6 extensive metabolisers (EMs). All subjects received a single oral dose of 7.5 mg olanzapine, and serum concentrations were… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism.

Drug metabolism and disposition: the biological fate of chemicals • 2015
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…