Olanzapine blocks the sympathetic and hyperthermic reactions due to cerebral injection of orexin A

  title={Olanzapine blocks the sympathetic and hyperthermic reactions due to cerebral injection of orexin A},
  author={M. Monda and An. Viggiano and A. Viggiano and R. Mondola and V. D. Luca},
  • M. Monda, An. Viggiano, +2 authors V. D. Luca
  • Published 2008
  • Medicine
  • Peptides
  • Since experiments regarding a possible relation between olanzapine and orexin A has been scarcely reported in international literature, this experiment tested the effect of olanzapine on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT, colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before an injection of orexin A (1.5 nmol… CONTINUE READING
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