Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex.

@article{Abekawa2008OlanzapineAR,
  title={Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex.},
  author={Tomohiro Abekawa and Koki Ito and Shin Nakagawa and Yasuya Nakato and Tsukasa Koyama},
  journal={Schizophrenia research},
  year={2008},
  volume={101 1-3},
  pages={84-94}
}
This study aims to propose a comprehensive new model for schizophrenia, which shows PPI disruption at baseline state as an endophenotype, the development of cross-sensitization to an NMDA receptor antagonist, MK-801 as a clinical phenotype of the progression into treatment-resistance, and accompanied induction of apoptosis in the medial prefrontal cortex as a critical possibility during the progression. Repeated administration of a high dose of methamphetamine (METH) (2.5 mg/kg), which could… CONTINUE READING
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