Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats

  title={Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats},
  author={Cheryl Anne Frye and Angela M. Seliga},
  journal={Physiology \& Behavior},
There is evidence that actions of both progesterone (P) and its metabolite, 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP), are important for sexual behavior of estradiol (E(2))-primed rodents. Olanzapine, an atypical antipsychotic, dose-dependently increases 3alpha,5alpha-THP in the cortex of male rats. These experiments investigated the effects of olanzapine administration on female sexual behavior and progestin concentrations. In Experiment 1, ovariectomized (ovx) rats (N=128) were… Expand
Effects of olanzapine infusions to the ventral tegmental area on lordosis and midbrain 3α,5α-THP concentrations in rats
Infusions of 10 or 20 μg olanzapine to the VTA significantly increased the incidence and intensity of lordosis, and the occurrence of proceptive and aggressive behaviors, which suggest that olanZapine's behavioral effects may result, in part, through actions of 3α,5α-THP, independent of progesterone or corticosterone. Expand
Olanzapine’s effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats
Olanzapine administration significantly increased plasma and produced non-significant increases in whole brain concentrations of progesterone and 3 alpha,5 alpha-THP compared to that seen following vehicle administration, consistent with the hypothesis that olanZapine reduces fear, has anxiolytic effects, and may enhance social interaction in part due to increasing progestin concentrations. Expand
Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors
3alpha,5alpha-THP's actions in the VTA for lordosis may involve D1 and/or D2 receptors. Expand
Progesterone’s effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors
The effects of P to decrease anxiety behavior of younger and older mice do not require classic PRs and may involve actions of 3α,5α-THP at GBRs. Expand
Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area
Data suggest that, in hamsters, P's actions for lordosis may involve D(1) receptors in the VTA, which is similar to the role that dopamine type 1 receptors play in humans. Expand
The Role of 3α-Hydroxy-5α-Pregnan-20-One in Mediating the Development and/or Expression of Schizophrenia Spectrum Disorders: Findings in Rodents Models and Clinical Populations
Neurosteroids, including 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP), mediate stress-responding, and the function and development of the central nervous system. 3α,5α-THP can be produced in the brain orExpand
Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in rats
It is concluded that chronic antipsychotic treatment disrupts active maternal behaviors and this disruption, most likely to lead to side effects in humans, should be avoided in future drug development. Expand
Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Findings suggest that neuroendocrine dysregulation among BTBR mice extends to 3alpha,5alpha-THP, a neurosteroid which can be rapidly produced de novo in the brain, independent of peripheral gland secretion, and can exert homeostatic effects to modulate stress-responding. Expand
Inhibition of stress-induced dopamine output in the rat prefrontal cortex by chronic treatment with olanzapine
The reduction in the sensitivity of cortical dopaminergic neurons to stress shown to be elicited by treatment with olanzapine or clozapine may contribute to the anxiolytic actions of these drugs. Expand


5α-reduced progesterone metabolites are essential in hamster VTA for sexual receptivity
4MA's reduction of receptivity when given systematically and intracranially strongly supports the hypothesis that 5α-reduced P metabolites, possibly interacting with GBRs in the VTA, are essential for sexual receptivity in hamsters. Expand
The neurosteroids, progesterone and 3α,5α-THP, enhance sexual motivation, receptivity, and proceptivity in female rats
It was revealed that 3α,5α-THP has a significant role in these reproductive measures and whole brain P levels were significantly reduced in paced mated rats compared to standard mated, and receptive non-mated animals. Expand
Olanzapine increases allopregnanolone in the rat cerebral cortex
Olanzapine-induced increases in the potent GABA(A) receptor modulator allopregnanolone may alter GABAergic neurotransmission, possibly contributing to antipsychotic efficacy, and neurosteroids may represent molecules for pharmacologic intervention. Expand
Progestins Can Have a Membrane-Mediated Action in Rat Midbrain for Facilitation of Sexual Receptivity
The data suggest that in rats P can act at the membrane of neurons within the VTA to modulate lordosis and that these effects may be subsequent to P's metabolism and/or actions at GABA receptors. Expand
5-HT2C receptor involvement in female rat lordosis behavior
The results are consistent with prior suggestions that 5-HT2A/2C receptors within the VMN are involved in the modulation of lordosis behavior and lead to the suggestion that 4-fluoro-phenylethyl, rather than 5- HT2A, receptors are primarily responsible for the effects of 5-ht2 receptor-active drugs on Lordosis behavior. Expand
Intravenous progesterone elicits a more rapid induction of lordosis in rats than does SKF38393
The present experiments suggest that actions at intracellular progestin receptors do not account for all of P’s effects to facilitate receptivity, and although PRs may be involved in P and D1 ligand”s activation of female sexual behavior, D1 receptors are not required for P“s effects. Expand
The effect of selective D1 and D2 dopaminergic agents on sexual receptivity in the female rat
The results indicate that a central dopaminergic system has an inhibitory control on female sexual activity exerted through D2 receptors, and the predominance of the D2 pre- and post-synaptic receptor activity appears to be influenced by the sexual receptivity of the animal. Expand
Facilitation of female rat lordosis behavior by hypothalamic infusion of 5-HT2A/2C receptor agonists
Results strengthen prior inferences that activation of 5-HT(2A/2C) receptors can facilitate lordosis behavior and that the VMN is one site at which such facilitation can occur. Expand
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice 1 1 Published on the World Wide Web on 20 April 2000.
It is demonstrated for the first time that serotonergic agents potentiate the antidepressant-like action of 3alpha, 5alpha THP, by enhancing the GABAergic tone as a likely consequence of increased brain content of this neurosteroid. Expand
The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid.
  • D. Finn, K. Gee
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1994
In vivo studies evaluated estrus cycle-related differences in sensitivity to convulsants and the anticonvulsant effect of 3 alpha, 5 alpha-P to find that females in estrus were more sensitive than females in diestrus 1 or males to (+)-bicuculline and methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3- carboxylate. Expand