Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats

@article{Frye2002OlanzapineAP,
  title={Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats},
  author={Cheryl Anne Frye and Angela M. Seliga},
  journal={Physiology \& Behavior},
  year={2002},
  volume={76},
  pages={151-158}
}
There is evidence that actions of both progesterone (P) and its metabolite, 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP), are important for sexual behavior of estradiol (E(2))-primed rodents. Olanzapine, an atypical antipsychotic, dose-dependently increases 3alpha,5alpha-THP in the cortex of male rats. These experiments investigated the effects of olanzapine administration on female sexual behavior and progestin concentrations. In Experiment 1, ovariectomized (ovx) rats (N=128) were… Expand
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