Olanzapine‐Associated Diabetes Mellitus

@article{Koller2002OlanzapineAssociatedDM,
  title={Olanzapine‐Associated Diabetes Mellitus},
  author={Elizabeth A. Koller and P. Murali Doraiswamy},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2002},
  volume={22}
}
  • E. Koller, P. Doraiswamy
  • Published 1 July 2002
  • Medicine, Psychology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Study Objective. To explore the clinical characteristics of hyperglycemia in patients treated with olanzapine. 

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Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

Study Objective. To investigate the relative numbers and clinical characteristics of pancreatitis in patients treated with the atypical antipsychotic agents, clozapine, olanzapine, and risperidone,
...

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TLDR
Clinicians should monitor blood glucose concentrations periodically in patients taking olanzapine, especially in those patients with risk factors for diabetes mellitus, especially after a 46-year-old African American woman who developed diabetic ketoacidosis was diagnosed with DKA and acute pancreatitis.

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TLDR
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TLDR
A 27-year-old African‐American man developed new‐onset severe hyperglycemia, with ketonuria and acidosis, but no weight gain, 2 years after starting olanzapine, although his diabetes was stabilized with insulin, his family had difficulty monitoring his therapy, and insulin was discontinued.

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TLDR
It appears that olanzapine caused hyperglycemia by a mechanism other than weight gain in this patient, and others from the literature suggest that oanzapine therapy may induce hyper glycemia in some patients.

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TLDR
Two psychotic patients developed hyperglycaemia several weeks after starting olanzapine, and in the second case severe ketoacidosis with letal outcome occured.

Olanzapine, new-onset diabetes mellitus, and risk for insulin overdose.

TLDR
It is suggested that the dose of antidepressant medication that leads to a satisfactory acute therapeutic response should be maintained during long-term treatment to prevent relapse or recurrence of depression.
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