Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response.

@article{Bishara2013OlanzapineAS,
  title={Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response.},
  author={Delia Bishara and Olubanke Olofinjana and Anna Sparshatt and Shitij Kapur and David McD Taylor and Maxine X. Patel},
  journal={Journal of clinical psychopharmacology},
  year={2013},
  volume={33 3},
  pages={329-35}
}
OBJECTIVE To conduct a systematic review examining the relationships between olanzapine dose, clinical outcome, dopamine occupancy, and plasma concentration; and to evaluate the potential for therapeutic drug monitoring. METHODS A search using Embase, Medline, and Pubmed was conducted; and the literature was systematically reviewed. Studies meeting inclusion criteria were examined. The relationships between olanzapine dose, response, dopamine occupancy, and concentration were analyzed using… CONTINUE READING