Olanzapine/fluoxetine combination in patients with treatment-resistant depression: rapid onset of therapeutic response and its predictive value for subsequent overall response in a pooled analysis of 5 studies.

@article{Tohen2010OlanzapinefluoxetineCI,
  title={Olanzapine/fluoxetine combination in patients with treatment-resistant depression: rapid onset of therapeutic response and its predictive value for subsequent overall response in a pooled analysis of 5 studies.},
  author={Mauricio Tohen and Michael A. Case and Madhukar H. Trivedi and Michael E. Thase and Scott J Burke and Todd M. Durell},
  journal={The Journal of clinical psychiatry},
  year={2010},
  volume={71 4},
  pages={451-62}
}
OBJECTIVE To characterize response profiles of olanzapine/fluoxetine combination therapy in treatment-resistant depression (TRD) and to investigate predictive relationships of early improvement with olanzapine/fluoxetine combination for subsequent response/remission during the acute phase of treatment. METHOD Results were pooled from 5 outpatient studies comparing oral olanzapine/fluoxetine combination, fluoxetine, or olanzapine for a maximum of 8 weeks in patients with TRD who had at least 1… CONTINUE READING

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