Olanzapine, but Not Fluoxetine, Treatment Increases Survival in Activity-Based Anorexia in Mice

@article{Klenotich2012OlanzapineBN,
  title={Olanzapine, but Not Fluoxetine, Treatment Increases Survival in Activity-Based Anorexia in Mice},
  author={Stephanie J. Klenotich and Mariel Patricia Seiglie and Matthew Stephen McMurray and Jamie D Roitman and W. Stewart Agras and Priya Dugad and Stephanie C. Dulawa},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={1620-1631}
}
Anorexia nervosa (AN) is an eating disorder characterized by extreme hypophagia, hyperactivity, and fear of weight gain. No approved pharmacological treatments exist for AN despite high mortality rates. The activity-based anorexia (ABA) phenomenon models aspects of AN in rodents, including progressive weight loss, reduced food intake, and hyperactivity. First, we optimized the ABA paradigm for mice. We compared mouse strains (Balb/cJ, A/J) for susceptibility with ABA, and evaluated the effects… CONTINUE READING
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