Okadaic acid uncouples calcium entry from depletion of intracellular stores.

Abstract

The mechanism by which the depletion of intracellular Ca2+ stores stimulates Ca2+ influx is poorly understood. However, the coupling of depletion to influx is broken during mitosis [Preston, S.F. et. al., (1991) Cell Regul., 2, 915-925]. Thus, in interphase HeLa cells, activation of the histamine H1 receptor, or incubation with thapsigargin, which inhibits… (More)

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