Okadaic acid suppresses melanogenesis via proteasomal degradation of tyrosinase.

  title={Okadaic acid suppresses melanogenesis via proteasomal degradation of tyrosinase.},
  author={Hyo-soon Jeong and Hye-young Yun and Kwang Jin Baek and Nyoun Soo Kwon and Kyoung-chan Park and Dong-Seok Kim},
  journal={Biological & pharmaceutical bulletin},
  volume={36 9},
Okadaic acid is a C38 fatty acid derivative that is known to specifically inhibit the activity of protein phosphatase 2A (PP2A). Previously, we reported that inhibition of PP2A by okadaic acid elicited extracellular signal-regulated kinase (ERK) activation, and that PP2A may be involved in melanogenesis. However, the effects of okadaic acid on melanogenesis have not been completely evaluated. In the present study, we investigated the molecular mechanisms involved in okadaic acid modulation of… CONTINUE READING

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Human skin pigmentation: melanocytes modulate skin color in response to stress.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007

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